Transplantation Immunology and Transplantation Rejection

The process of moving cells, tissues, or organs from one location to another, either within the same person or between a donor and a recipient, is known as transplantation. An organ system can be replaced with a healthy organ or tissue from a donor if it fails or becomes damaged as a result of disease or injury. Organ transplantation is a serious procedure that is only considered after all other treatment options have been exhausted. Every year, it saves hundreds of lives. When tissues/organs are moved from one person to another, however, the immune system poses a considerable barrier to effective organ transplantation. When the immune system recognises a transplant as foreign, it triggers a response that eventually destroys the transplanted organ or tissue. The transplant's long-term survival can be ensured by modulating the immune system to lessen the likelihood of rejection. Prior to transplantation, the donor and recipient are carefully matched to reduce the chance of rejection. They're matched based on blood type, tissue type, and how the recipient's blood serum reacts to the donor cells. Immunosuppressive medicines, which reduce the total immune response, are used to prevent and treat transplant rejection. Immunosuppressive medications, on the other hand, are non-specific, making patients more susceptible to disease and causing a slew of unwanted side effects.

• Immunosuppression
• Immunosuppressive Drugs
• Immunological Mechanisms of Rejection