Immunological Tolerance

The immune system can distinguish between molecules produced by the body and those that are not. It can thereby target foreign bodies while avoiding antigens produced by itself. This process, when working well, prevents misdirected immune responses to non-harmful antigens, but if something goes wrong, it might result in allergies or autoimmune illnesses. Immune tolerance, also known as immunological tolerance or immunotolerance, is an active condition of non-response to specific antigens in order to prevent the immune system from becoming overly reactive. It stops the immune system from reacting to antigens produced by the body or recognised from a previous contact. Self-tolerance and induced tolerance are the two types of immunological tolerance. Normal physiology relies on immune tolerance. The immune system learns to distinguish self from non-self mostly through central tolerance. Peripheral tolerance is essential for preventing immune system over-reactivity to diverse environmental agents (allergens, gut microbes, etc.).

• Self-Tolerance
• Induced Tolerance
• Tolerance in Physiology and Medicine
• Oral Tolerance and Hypersensitivity
• Tumor Microenvironment