Mirza Muhammad Faran Ashraf Baig

Title : Recent advances of magnetic gold hybrids and nanocomposites, and their potential biological applications

Abstract:

Magnetic gold nanoparticles (mGNP) have become a great interest of research for nanomaterial scientists because of their significant magnetic and plasmonic properties applicable in biomedical applications. Various synthetic approaches and surface modification techniques have been used for mGNP including the most common being the coprecipitation, thermal decomposition, and microemulsion methods in addition to the Brust Schiffrin technique, which involves the reduction of metal precursors in a two-phase system (water and toluene) in the presence of alkanethiol. The hybrid magnetic–plasmonic nanoparticles based on iron core and gold shell are being considered as potential theragnostic agents. Herein, in addition to future works, we will discuss recent developments for synthesis and surface modification of mGNP with their applications in modern biomedical science such as drug and gene delivery, bioimaging, biosensing, and neuro-regenerative disorders. I shall also discuss the techniques based on my research related to the biological applications of mGNP.

Keywords:
Nanohybrids; magnetic gold nanoparticles; nanocomposites; surface functionalization; core-shell nanocomposites; magnetic-plasmonic nanoparticles; biological applications

Biography:

My research work mainly focuses on the construction and function of DNA nanomachines, which are cutting-edge and challenging topics. I designed and constructed unique DNA motifs using a short circular DNA nanotechnology technique and functionalized these probes with fluorophores, gold nanoparticles, small molecular drugs, and peptide ligands. To achieve plasmon resonance effects, I achieved nano-specific precision in organizing plasmonic nanoparticles on the nano DNA frameworks. My work on the DNA nanomachines provided an efficient fluorescence resonance energy transfer mechanism that realizes the bio-imaging, detection of biological events, and functions of the biomolecules. I have also been working on multilayered hybrid magnetic nanoparticles for applications in nanomedicine for the last three years.