Mohamed Labib Salem, Speaker at Clinical Immunology Conferences
Tanta University, Egypt
Title : The severity of COVID-19 shifts the cytokine and chemokine milieu toward the proinflammatory environment

Abstract:

Cytokine storm, the production of many pro-and inflammatory cytokines such as IL-1, IL-6, and TNF-a, is linked to the severity of illness associated with COVID-19. Several recent studies have found varying levels of inflammatory cytokines in COVID-19 patients' plasma, primarily related to severe infection. These studies, however, neither analyzed the entire storm nor compared it in patients with different degrees of severity. We designed this study to evaluate the cytokine/chemokine axis related to cytokine storms. To this end, we used a highly standardized Luminex assay to analyze 25 cytokines/chemokines in plasma from 89 male and female patients with different degrees of COVID-19. The patients were divided into five categories based on the severity of their COVID-19 symptoms: healthy, mildly infected, moderately ill, severely ill, and critically ill. The cytokines/chemokines axis evaluated include those associated with inflammation, thrombosis, lung injury, and immunological modulation. Our research revealed substantial variations in many cytokines. IL-2R, IL-8, IL-13, IL-1-α, IL-8, TNF-, and IP10 levels were significantly altered in severe and critically ill patients compared to other groups. Our findings could open new avenues to use these cytokines/ chemokines as a predictor or prognostic biomarker for the severity of COVID-19 and their responses to treatment.

Biography:

Prof. Salem (PhD, 1995) is the Prof. of Immunology at Tanta University, Egypt.Dr. Salem is the Founder and Director of Center of Excellence in Cancer Research, Tanta University, Egypt; Founder, and Chairman of Egyptian Association for Cancer Research. He is among the founding members of the Middle Eastern Association for Cancer Research, Canada. Dr. Salem is the General Supervisor of Delta Development Research Centre, Academy of Scientific Research and Technology, Egypt; Ex-Director of the Grant, Innovation& Technology Transfer Centre; Member of the Executive Board of Directors, Zewail City, Supervision Board Committee, New Egyptian Community Universities; Scientific Advisor to Galala University and Regional Development Centre, Academy of Scientific Research and Technology, Egypt. He was Visiting Prof at Medical University of South Carolina, USA.

Dr. Salem obtained his BSc (Zoology) in 1984, his MSc (Comparative Vertebrate Anatomy),in 1989, and PhD (Immunology) in 1995 from Faculty of Science, Tanta University, Egypt. He was appointed as Demonstrator in 1984, Assistant Lecturer in 1989 and Lecturer in1996 at Zoology Department, Faculty of Science, Tanta University. He obtained a PhD grant from Egypt (Channel System) to study Immunology Department, Kyushu University, Japan from 10/1992-1/1995 and a Japanese Postdoctoral Fellowship at the same department from 10/1997-3/2001. He worked as an Ass. Prof. from 2001-2010 at Surgery Department, Hollings Cancer Centre, Medical University of South Carolina, USA.

Watsapp