Title : The immunomodulatory effects of Frankincense extract in suppression of experimental autoimmune encephalomyelitis
Abstract:
Background: Multiple Sclerosis (MS) is a chronic neurodegenerative disease of the central nervous system. The main feature of this disease is the formation of inflammatory lesions in the white matter of the brain and spinal cord due to inappropriate immune responses against the myelin sheath. Frankincense is known as “Kondor” in Persian language has been mentioned in the ancient history of Iranian traditional medicine as herbal remedy for pain relief and wound healing. The Positive anti-inflammatory activity of Frankincense extract has reported in several studies. The present study aims to investigate the effect of Frankincense hydroalcoholic extract in Experimental autoimmune encephalomyelitis in C57BL / 6 mice.
Material and Methods: In this experimental study, female C57BL / 6 mice were divided into three groups including normal group without EAE, PBS-treated EAE group without receiving Frankincense extract, the third group were administered a single oral dose of 200 mg/kg body weight Frankincense alcoholic extract for 33 days. On day 33 post-immunization, spleens were removed and cultured for analyzing of cytokine.
Results: The evaluation of results showed that the level of inflammatory cytokines was significantly reduced in the Treatment group compared to the EAE group.
Conclusions: These observations indicate that Frankincense hydroalcoholic extract reduces the severity of EAE, inflammatory cytokines and attenuate signs of EAE.
