Zhaohua Zhou, Food and Drug Administration, United States
Polyethylene glycol (PEG)- modification (PEGylation) is a highly successful strategy for improving the therapeutic properties of protein products. PEGylation increases protein size, inhibits proteolysis and decreases renal filtration, thereby improving the pharmacokinetics (half- [....]
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Ismail Osmanov, Children's city clinical hospital, Russian Federation
Virus-neutralizing monoclonal antibodies (mAbs) are designed to create a passive or enhance the natural immune response against a foreign agent. For the first time, the introduction of monoclonal antibodies to children for the treatment of new coronavirus infection (hereinafter r [....]
» Read More
Multiple sclerosis (MS) is one of the most common causes of neurological dysfunction representing unmet medical need, which demands novel therapies toward a cure. Experimental autoimmune encephalomyelitis (EAE) is the most commonly used model for studying autoimmune-mediated myel [....]
» Read More
Adoptive immunotherapy with ex vivo expanded, polyspecific regulatory T cells (Tregs) is a promising treatment for graft-versus-host disease. Animal transplantation models used by us and others have demonstrated that the adoptive transfer of allospecific Tregs offers greater prot [....]
» Read More
Non–small cell lung carcinoma (NSCLC) is known to evade host immune defenses via a downregulation of the immune response. One of the molecules involved in this mechanism is programmed cell death ligand 1 (PD-L1), which interacts with its receptor, programmed cell death prot [....]
» Read More
Cytokine storm, the production of many pro-and inflammatory cytokines such as IL-1, IL-6, and TNF-a, is linked to the severity of illness associated with COVID-19. Several recent studies have found varying levels of inflammatory cytokines in COVID-19 patients' plasma, primari [....]
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Alec Bigness, University of South Florida Morsani College of Medicine, United States
Introduction
Highly active antiretroviral therapy (HAART) has substantially reduced the prevalence of Kaposi Sarcoma (KS),1,2 yet its effectivity has rendered a new phenomenon, KS-IRIS, a serious condition where patients experience paradoxical worsening after HAART initiation th [....]
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Autoimmune hepatitis (AIH) is a chronic autoimmune inflammatory disease that usually requires life-long immunosuppression. Frequent relapses after discontinuation of therapy indicate that intrahepatic immune regulation is not restored by current therapies. As steroid therapy pref [....]
» Read More
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with around 0.1% global incidence, which is characterized by loss of tolerance to ubiquitous self-antigens, high titres of autoantibodies directed against nuclear components such as double-stranded DNA an [....]
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Title : Mast cell degranulation links anti-PEG IgE to anaphylaxis caused by PEGylated drugs and PEG-contained LNP/mRNA COVID vaccines
Zhaohua Zhou, Food and Drug Administration, United States
Polyethylene glycol (PEG)- modification (PEGylation) is a highly successful strategy for improving the therapeutic properties of protein products. PEGylation increases protein size, inhibits proteolysis and decreases renal filtration, thereby improving the pharmacokinetics (half- [....] » Read More
Title : Monoclonal antibodies efficacy in treatment of novel coronavirus infection (COVID-19) in children at risk of developing a severe course of the disease
Ismail Osmanov, Children's city clinical hospital, Russian Federation
Virus-neutralizing monoclonal antibodies (mAbs) are designed to create a passive or enhance the natural immune response against a foreign agent. For the first time, the introduction of monoclonal antibodies to children for the treatment of new coronavirus infection (hereinafter r [....] » Read More
Title : Considerations on MS animal modeling: Format of myelin immunogens used for experimental autoimmune encephalomyelitis model establishment may affect pharmacologic responses of anti-inflammatory drugs
WenQing Yang, Simcere Pharma Group, China
Multiple sclerosis (MS) is one of the most common causes of neurological dysfunction representing unmet medical need, which demands novel therapies toward a cure. Experimental autoimmune encephalomyelitis (EAE) is the most commonly used model for studying autoimmune-mediated myel [....] » Read More
Title : Regulatory T cells with chimeric antigen receptors as treatment for autoimmunity
Matthias Hardtke Wolenski, Hannover Medical School, Germany
Adoptive immunotherapy with ex vivo expanded, polyspecific regulatory T cells (Tregs) is a promising treatment for graft-versus-host disease. Animal transplantation models used by us and others have demonstrated that the adoptive transfer of allospecific Tregs offers greater prot [....] » Read More
Title : PD-1/PD-L1 interaction is a predictive biomarker to stratify NSCLC lung cancer patients to immunotherapy
Lissete Sanchez Magraner, Fast Base solutions, Spain
Non–small cell lung carcinoma (NSCLC) is known to evade host immune defenses via a downregulation of the immune response. One of the molecules involved in this mechanism is programmed cell death ligand 1 (PD-L1), which interacts with its receptor, programmed cell death prot [....] » Read More
Title : The severity of COVID-19 shifts the cytokine and chemokine milieu toward the proinflammatory environment
Mohamed Labib Salem, Tanta University, Egypt
Cytokine storm, the production of many pro-and inflammatory cytokines such as IL-1, IL-6, and TNF-a, is linked to the severity of illness associated with COVID-19. Several recent studies have found varying levels of inflammatory cytokines in COVID-19 patients' plasma, primari [....] » Read More
Title : Kaposi Sarcoma Associated Immune Reconstitution Inflammatory Syndrome (Ks-Iris) – Recognition And Treatment In The Age of Advancing Antiretroviral Therapy
Alec Bigness, University of South Florida Morsani College of Medicine, United States
Introduction Highly active antiretroviral therapy (HAART) has substantially reduced the prevalence of Kaposi Sarcoma (KS),1,2 yet its effectivity has rendered a new phenomenon, KS-IRIS, a serious condition where patients experience paradoxical worsening after HAART initiation th [....] » Read More
Title : Treg-specific IL-2 therapy can reestablish intrahepatic immune regulation in autoimmune hepatitis
Laura Elisa Buitrago Molina, Hannover Medical School, Germany
Autoimmune hepatitis (AIH) is a chronic autoimmune inflammatory disease that usually requires life-long immunosuppression. Frequent relapses after discontinuation of therapy indicate that intrahepatic immune regulation is not restored by current therapies. As steroid therapy pref [....] » Read More
Title : NCF1-dependent low production of reactive oxygen species in plasmacytoid dendritic cells exacerbates lupus
Huqiao Luo, Karolinska Institute, Sweden
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with around 0.1% global incidence, which is characterized by loss of tolerance to ubiquitous self-antigens, high titres of autoantibodies directed against nuclear components such as double-stranded DNA an [....] » Read More