Adoptive immunotherapy with ex vivo expanded, polyspecific regulatory T cells (Tregs) is a promising treatment for graft-versus-host disease. Animal transplantation models used by us and others have demonstrated that the adoptive transfer of allospecific Tregs offers greater prot [....]
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Cytokine storm, the production of many pro-and inflammatory cytokines such as IL-1, IL-6, and TNF-a, is linked to the severity of illness associated with COVID-19. Several recent studies have found varying levels of inflammatory cytokines in COVID-19 patients' plasma, primari [....]
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Autoimmune hepatitis (AIH) is a chronic autoimmune inflammatory disease that usually requires life-long immunosuppression. Frequent relapses after discontinuation of therapy indicate that intrahepatic immune regulation is not restored by current therapies. As steroid therapy pref [....]
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Alec Bigness, University of South Florida Morsani College of Medicine, United States
Introduction
Highly active antiretroviral therapy (HAART) has substantially reduced the prevalence of Kaposi Sarcoma (KS),1,2 yet its effectivity has rendered a new phenomenon, KS-IRIS, a serious condition where patients experience paradoxical worsening after HAART initiation th [....]
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Title : Regulatory T cells with chimeric antigen receptors as treatment for autoimmunity
Matthias Hardtke Wolenski, Hannover Medical School, Germany
Adoptive immunotherapy with ex vivo expanded, polyspecific regulatory T cells (Tregs) is a promising treatment for graft-versus-host disease. Animal transplantation models used by us and others have demonstrated that the adoptive transfer of allospecific Tregs offers greater prot [....] » Read More
Title : The severity of COVID-19 shifts the cytokine and chemokine milieu toward the proinflammatory environment
Mohamed Labib Salem, Tanta University, Egypt
Cytokine storm, the production of many pro-and inflammatory cytokines such as IL-1, IL-6, and TNF-a, is linked to the severity of illness associated with COVID-19. Several recent studies have found varying levels of inflammatory cytokines in COVID-19 patients' plasma, primari [....] » Read More
Title : Treg-specific IL-2 therapy can reestablish intrahepatic immune regulation in autoimmune hepatitis
Laura Elisa Buitrago Molina, Hannover Medical School, Germany
Autoimmune hepatitis (AIH) is a chronic autoimmune inflammatory disease that usually requires life-long immunosuppression. Frequent relapses after discontinuation of therapy indicate that intrahepatic immune regulation is not restored by current therapies. As steroid therapy pref [....] » Read More
Title : Kaposi Sarcoma Associated Immune Reconstitution Inflammatory Syndrome (Ks-Iris) – Recognition And Treatment In The Age of Advancing Antiretroviral Therapy
Alec Bigness, University of South Florida Morsani College of Medicine, United States
Introduction Highly active antiretroviral therapy (HAART) has substantially reduced the prevalence of Kaposi Sarcoma (KS),1,2 yet its effectivity has rendered a new phenomenon, KS-IRIS, a serious condition where patients experience paradoxical worsening after HAART initiation th [....] » Read More